my father is 65yr old. he has chronic liver disease alcholic cirrhosis . post evl x3 his liver enzymes are normal except slight increase in bilirubin. other labs are ok except mild hyponat of 130-133 ascites has resided for now. alcohol intake stopped for 2yrs now except one time during the feast. past 1 month his mental state is declining : hallucinations both visual and sometimes auditory ?, delusion of staying at others homes not own , memory problems immediate and recent past : does not recognize rooms and places at his own house but can tell where he is sometimes but gets confused mostly, confuses relatives and family members from distant past, restlessness, night time awakening, day time wanderings around house being confused, had febrile episode for 2days with dry cough. he has been chronic smoker until recently decreased intake and now we have atopped him from going out compleely due to his menal state as well as corona situation , his chest x ray showed left basal pneumonia. covid tested positive. rest of the lab are ok. vital signs are stable. consulted with both neuro and hepato- medicines continued now are lactitol, heptaorange, folic acid , vit b12, rifaximine, ursodecholic, amoxiclav, azith and quetiapine . quetapine was started at 12.5 mg and by 3rd week increased to 25 mg od sometimes bd but the effect is not satisfactory regarding his sx for pas few days some days he cant even sleep whole night and gets agitated during daytime for preventing him to go out... whst can we do now in present circumstances....is it due to use of rifaximine ? or something to do with timing of drug or its metabolism ? how safely we can taper the dose of drug for its maximum effect regarding the delusions and its antipsychotic effect...